Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Alzheimer's Disease: Treatment

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sex differences in blood pressure hemodynamics and white matter hyperintensity volume across racial ethnic groups-HABS-HD.

Alzheimer's & dementia (New York, N. Y.)·2026

Same author

Developing an Equitable Machine Learning-Based Music Intervention for Older Adults At Risk for Alzheimer Disease: Protocol for Algorithm Development and Validation.

JMIR research protocols·2025

Same author

Caring for the Caregiver: Investigating the Relationship Between Caregiving, Gender, and Diabetes Risk in MIDUS II.

Journal of applied gerontology : the official journal of the Southern Gerontological Society·2025

Same author

A critical examination of the relationship between cardiovascular health, cognition, and dementia risk.

Journal of Alzheimer's disease : JAD·2025

Same author

The Effects of Time-Restricted Feeding on Handgrip Strength, Vigilance, and Perceived Anxiety and Depression in Older Adults: A Comparative Study Between Active and Sedentary Populations.

Health science reports·2025

Same author

The impact of exercise interventions on sleep in adult populations with depression, anxiety, or posttraumatic stress: review of the current evidence and future directions.

Journal of behavioral medicine·2024

Search research articles

Related Experiment Video

Updated: Oct 4, 2025

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

Intervention for a Digital, Cognitive, Multi-Domain Alzheimer Risk Velocity Study: Protocol for a Randomized

Michelle Gray¹, Erica N Madero², Joshua L Gills¹

¹Exercise Science Research Center, Department of Health, Human Performance, and Recreation, University of Arkansas, Fayetteville, AR, United States.

JMIR Research Protocols

|February 4, 2022

Summary

A digital lifestyle intervention shows no significant difference in reducing Alzheimer disease (AD) risk in middle-aged and older adults. Further research is needed to explore the impact of digital health coaching on AD prevention strategies.

Keywords:

Alzheimer risk digital health health coaching mobile phone

More Related Videos

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

Related Experiment Videos

Last Updated: Oct 4, 2025

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

Area of Science:

Gerontology
Neuroscience
Public Health

Background:

Alzheimer disease (AD) affects over 6 million US adults, with 1 in 3 older adults impacted.
Lifestyle interventions show promise in slowing cognitive decline and delaying AD onset.
Existing research often focuses on older populations and in-person interventions.

Purpose of the Study:

To evaluate a 2-year digital lifestyle intervention's effect on Alzheimer disease (AD) risk.
To compare the intervention group with a health education control group.
To assess impact on at-risk middle-aged and older adults aged 45-75 years.

Main Methods:

A digitally delivered, personalized health coaching program targeting modifiable AD risk factors.
Primary outcome: Alzheimer Disease Risk Index (ADRI).
Secondary outcomes: functional fitness, blood biomarkers (inflammation, glucose, cholesterol, triglycerides), and cognitive function.

Main Results:

No significant difference in AD risk between the intervention and control groups at baseline (P=.90).
Baseline AD risk scores were comparable between groups (mean -1.68, SD 7.31).

Conclusions:

The Digital, Cognitive, Multi-domain Alzheimer Risk Velocity intervention is designed to mitigate AD risk.
The web-based program addresses modifiable, lifestyle-based risk factors.
Further investigation into the efficacy of digital health coaching for AD risk reduction is warranted.