Role of microalgal metabolites in controlling quorum-sensing-regulated biofilm

Bacterial infections are primarily caused due to the formation of biofilms on the surfaces. The formation of bacterial biofilms results in 60-70% of nosocomial infections in hospital-acquired infections for multidrug-resistant bacteria. Quorum-sensing (QS) is the process of cell-cell communications among bacterial cells. The formation and regulation of biofilm-producing signaling molecules, competence for DNA uptake and factors responsible for virulence occur. When the bacterial cell population density increases, auto-inducers bind with QS receptors and induce gene expression. To suppress the expression of the virulence genes, certain antibiotics and small molecules are used against the pathogenic bacteria. Since the microorganisms are becoming resistant to antibiotics, there is a need of new compounds or molecules which can suppress or inhibit the expression or regulation of virulence genes. Microalgae are an important and rich source of bioactive compounds which have the antimicrobial property. Microalgae have various antibacterial metabolites, such as Portoamides (peptides), flavonoids, eicosapentaenoic acid, alkaloids, peptides and many other secondary metabolites. This review focuses on the signaling molecule-regulated QS mechanism, biofilm formation, and microalgae compounds' effects against pathogenic bacteria. Consequently, most of the compounds have made it to the different levels of clinical trials, even some of the compounds are used therapeutically. Despite the promising applications of antibacterial peptides and the importance of searching for new natural sources of antibiotics, limitations persist for their pharmaceutical applications. However, given due research impetus, these marine metabolites might emerge as a new wave of promising drugs.