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Conjugated Proteins

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...

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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

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Stimulus-Responsive Nanoconjugates Derived from Phytoglycogen Nanoparticles.

Yingshan Ma¹, Vahid Adibnia^1,2, Monica Mitrache¹

¹Department of Chemistry, University of Toronto, Toronto M5S 3H6, Ontario, Canada.

Biomacromolecules

|February 4, 2022

Summary

This summary is machine-generated.

Researchers developed plant-derived phytoglycogen nanoparticles (PhG NPs) for drug delivery. These novel nanoconjugates enable controlled release of methotrexate (MTX), offering potential for cancer and arthritis treatments.

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Area of Science:

Biomaterials Science
Nanotechnology
Drug Delivery Systems

Background:

Plant-derived phytoglycogen nanoparticles (PhG NPs) offer size uniformity, water dispersibility, lubrication, and low cytotoxicity.
Chemical functionalization of PhG NPs can compromise their structural integrity.

Purpose of the Study:

To develop a straightforward method for creating PhG NP conjugates with biologically active molecules.
To functionalize PhG NPs with methotrexate (MTX) for potential therapeutic applications.

Main Methods:

Utilized hydrogen bonding between bovine serum albumin (BSA) and electroneutral PhG NPs.
Achieved electrostatically governed attachment of MTX to BSA-capped PhG NPs.
Investigated stimuli-responsive MTX release under varying temperature and ionic strength.

Main Results:

Successfully generated BSA-capped PhG NPs with enhanced ligand binding affinity.
Demonstrated the attachment of the therapeutic agent MTX to the protein-capped NPs.
Confirmed stimuli-responsive release of MTX from the PhG-based nanoconjugates.

Conclusions:

Developed a simple approach for creating PhG NP-drug conjugates.
PhG NP nanoconjugates exhibit stimuli-responsive drug release properties.
This study encourages further research into the biomedical applications of PhG NP nanoconjugates.