Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

235
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
235
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

437
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
437
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

10
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
10

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unraveling the refolding dynamics, TLR2 interaction, and immunomodulatory insights of OmpA from Salmonella Typhimurium.

Microbial pathogenesis·2026
Same author

Field-ready DNA extraction from scat using magnetic nanoparticles for non-invasive wildlife monitoring.

Scientific reports·2026
Same author

Biophysical and functional insights into YchP, a putative invasin outer membrane protein of Salmonella Typhimurium, and its role in virulence.

International journal of biological macromolecules·2025
Same author

Engineering outer membrane vesicles (OMVs) carrying OmpA from S. Typhimurium for targeted modulation of human B-cell function through AID expression and class switch recombination.

Microbial pathogenesis·2025
Same author

Unravelling the Impact of Outer Membrane Protein, OmpA, From S. Typhimurium on Aberrant AID Expression and IgM to IgA Class Switching in Human B-Cells.

Immunology·2025
Same author

Defining an NK Cell-enriched Rejection-like Phenotype in Liver Transplant Biopsies From the INTERLIVER Study.

Transplantation·2025
Same journal

Does taking BP medicine at night (vs morning) result in fewer cardiovascular events?

The Journal of family practice·2023
Same journal

Preventing RSV in children and adults: A vaccine update.

The Journal of family practice·2023
Same journal

Essential oils: How safe? How effective?

The Journal of family practice·2023
Same journal

51-year-old woman • History of Graves disease • General fatigue, palpitations, and hand tremors • Dx?

The Journal of family practice·2023
Same journal

Renewing the dream.

The Journal of family practice·2023
Same journal

55-year-old woman • Myalgias and progressive symmetrical proximal weakness • History of unilateral renal agenesis, type 2 diabetes, and hyperlipidemia • Dx?

The Journal of family practice·2023
See all related articles

Related Experiment Video

Updated: Oct 4, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.1K

Using biomarkers to quantify problematic alcohol use.

Rahul Chaudhari1, Dilip Moonka2, Frederick Nunes1

  • 1Pennsylvania Hospital of University of Pennsylvania, Philadelphia.

The Journal of Family Practice
|February 4, 2022
PubMed
Summary
This summary is machine-generated.

Direct biomarkers can detect recent alcohol consumption. Phosphatidylethanol (PEth) is a highly specific biomarker for alcohol use, even in small amounts shortly after drinking.

More Related Videos

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
05:40

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans

Published on: April 28, 2022

3.2K
Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

8.1K

Related Experiment Videos

Last Updated: Oct 4, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.1K
The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
05:40

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans

Published on: April 28, 2022

3.2K
Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

8.1K

Area of Science:

  • Biomarkers
  • Alcohol Metabolism
  • Toxicology

Background:

  • Direct biomarkers offer sensitive detection of recent alcohol consumption.
  • Specificity remains a challenge for many existing alcohol biomarkers.

Purpose of the Study:

  • To identify a highly specific direct biomarker for alcohol use.
  • To evaluate the diagnostic accuracy of biomarkers for recent alcohol ingestion.

Main Methods:

  • Review of scientific literature on direct alcohol biomarkers.
  • Analysis of studies reporting specificity and sensitivity of biomarkers like phosphatidylethanol (PEth).

Main Results:

  • Phosphatidylethanol (PEth) demonstrates nearly 100% specificity for alcohol consumption.
  • PEth can detect alcohol use even in small amounts shortly after ingestion.

Conclusions:

  • Phosphatidylethanol (PEth) is a highly specific biomarker for detecting recent alcohol use.
  • PEth offers superior specificity compared to other direct alcohol biomarkers.