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Serum uric acid concentration is associated with hyperhomocysteinemia in hypertensive Chinese adults

Wen Wang1, Qian Wang, Nan Yang

  • 1The Second Affiliated Hospital, Xi'an Jiaotong University, Xincheng District, Xi'an City, Shaanxi Province, China.

Blood Pressure Monitoring
|February 4, 2022
PubMed

Insights

Elevated serum uric acid levels are linked to a higher risk of hyperhomocysteinemia in Chinese hypertensive adults. This finding suggests serum uric acid may serve as an independent indicator for this condition.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Chemistry
  • Epidemiology

Background:

  • Hyperhomocysteinemia is a risk factor for cardiovascular disease.
  • Hypertension is a prevalent condition associated with increased cardiovascular risk.
  • The relationship between serum uric acid and hyperhomocysteinemia in hypertensive patients requires further investigation.

Purpose of the Study:

  • To investigate the correlation between serum uric acid levels and hyperhomocysteinemia in Chinese adult patients with hypertension.
  • To determine if elevated serum uric acid is an independent risk factor for hyperhomocysteinemia in this population.

Main Methods:

  • A cohort of 981 hypertensive patients was analyzed.
  • Patients were categorized based on the presence or absence of hyperhomocysteinemia.
  • Serum uric acid levels were stratified into quartiles, and logistic regression analysis was employed to assess the association with hyperhomocysteinemia risk.

Main Results:

  • A significant positive correlation was observed between higher serum uric acid levels and the prevalence of hyperhomocysteinemia.
  • Patients in the highest quartile of serum uric acid had a significantly increased risk of hyperhomocysteinemia (OR = 3.00, 95% CI: 1.83-4.93) compared to the lowest quartile.
  • Significant differences in gender, BMI, serum creatinine, total cholesterol, and diastolic blood pressure were noted between hyperhomocysteinemia and non-hyperhomocysteinemia groups.

Conclusions:

  • Elevated serum uric acid levels are independently associated with hyperhomocysteinemia in Chinese hypertensive patients.
  • Serum uric acid may serve as a valuable biomarker for identifying hypertensive individuals at higher risk of hyperhomocysteinemia.
  • Further research is warranted to explore the underlying mechanisms and clinical implications.
Abstract

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