Related Experiment Video
Updated: Oct 4, 2025

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
Published on: November 1, 2018
Constructing and validating a transferable epidemic risk index in data scarce environments using open data: A case
Fleur Hierink1,2, Jacopo Margutti3, Marc van den Homberg3
1Institute of Global Health, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Developing a novel epidemic risk index using open data aids early infectious disease detection and prevention. This dengue risk index in the Philippines shows strong correlation with epidemiological data, enabling better public health decisions.
Area of Science:
- Epidemiology and Public Health
- Infectious Disease Modeling
- Risk Assessment
Background:
- Epidemics pose significant global economic and social threats.
- Current infectious disease control often relies on emergency response rather than proactive measures.
- A scalable, open-data-driven epidemic risk index is needed for early detection and prevention.
Purpose of the Study:
- To introduce and validate a methodology for constructing a scalable epidemic risk index using open data.
- To apply this index to assess dengue risk in the Philippines.
- To demonstrate the index's utility for public health decision-making.
Main Methods:
- Developed a methodology for an epidemic risk index using open-source data.
- Employed distance sampling to correct for underreporting of infections based on healthcare accessibility.
- Validated the index against epidemiological metrics like dengue incidence and case fatality rate (CFR).
Main Results:
- The computed dengue risk index showed a significant correlation with dengue incidence (p = 0.002).
- Susceptibility was a key dimension, correlating with incidence (p = 0.048) and CFR (p = 0.029).
- Highest dengue risk was identified in southern Philippines, linked to high susceptibility.
Conclusions:
- The developed epidemic risk index accurately reflects sub-national dengue disease patterns.
- The methodology provides a practical, evidence-based tool for disease risk assessment, especially when timely data is scarce.
- This index enhances public health and humanitarian decision-making through simple, actionable metrics.
Related Concept Videos
Steps in Outbreak Investigation
Statistical Methods for Analyzing Epidemiological Data
Principles of Disease Surveillance
Introduction to Epidemiology
Statistical Software for Data Analysis and Clinical Trials
Causality in Epidemiology

