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A portable fan-based device for evaluating lung function in horses by the forced oscillation technique.
Davide Bizzotto1, Stefano Paganini1, Luca Stucchi2
1TechRes Lab, Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano University, Milan, Italy.
Physiological Measurement
|February 4, 2022
Summary
A new portable device uses the forced oscillation technique (FOT) for non-invasive lung mechanics assessment in horses. This innovation offers a more accessible and accurate method for diagnosing respiratory conditions in equine medicine.
Area of Science:
- Veterinary Medicine
- Respiratory Physiology
- Biomedical Engineering
Background:
- Current methods for assessing equine lung mechanics are invasive, often requiring sedation.
- Existing forced oscillation technique (FOT) devices are complex, bulky, and costly for equine application.
- There is a need for non-invasive, portable, and user-friendly tools to evaluate respiratory mechanics in horses.
Purpose of the Study:
- To develop a novel, portable forced oscillation technique (FOT) device for non-invasive assessment of respiratory mechanics in horses.
- To evaluate the feasibility, tolerability, and accuracy of the developed FOT device in horses.
- To differentiate respiratory mechanics between healthy horses and those with severe equine asthma (SEA).
Main Methods:
- Development of a portable FOT device utilizing a servo-controlled ducted fan for pressure waveform generation.
- Integration of a microcontroller-based electronic board for system control and data acquisition (flow and pressure).
- Implementation of an optimized data processing algorithm for calculating respiratory resistance and reactance.
- In-vitro validation and a pilot study involving healthy horses and horses with SEA.
Main Results:
- The device demonstrated high accuracy in in-vitro validation, with maximum errors of 0.06 cmH2O·s/L for resistance and 0.15 cmH2O·s/L for reactance.
- The pilot study confirmed good tolerability and feasibility of the portable FOT device in horses.
- Significant differences in total respiratory system resistance (Rrs) and reactance (Xrs) were observed between healthy and SEA horses (p < 0.05).
Conclusions:
- The developed portable FOT device offers a small, affordable, and robust solution for non-invasive respiratory mechanics evaluation in spontaneously breathing horses.
- This novel device represents a valuable advancement for veterinary respiratory medicine, aiding in the diagnosis and management of equine respiratory diseases.
- The underlying approach shows promise for the development of similar portable FOT devices for human applications.
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