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Updated: Oct 4, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

967

Circular RNA expression profile and competing endogenous RNA regulatory network in preeclampsia

Yuan Yuan1, Yunhui Gong2, Lu Zhong1

  • 1Department of Gynecology and Obstetrics, The 3rd Affiliated Hospital of Chengdu Medical College, Pidu District People's Hospital, Chengdu, China.

Placenta
|February 5, 2022
PubMed

Insights

This study explored circular RNAs (circRNAs) in preeclampsia (PE), identifying key circRNA-miRNA-mRNA pathways like hsa_circRNA_0001687/hsa-miR-532-3p/MMP14/AXL that may contribute to PE's pathology.

Area of Science:

  • Genomics
  • Molecular Biology
  • Obstetrics

Background:

  • Preeclampsia (PE) is a pregnancy-specific disorder linked to significant maternal and neonatal complications.
  • Understanding the molecular mechanisms underlying PE is crucial for improving maternal and neonatal outcomes.

Purpose of the Study:

  • To investigate the role of circular RNAs (circRNAs) in the pathogenesis of preeclampsia.
  • To identify potential diagnostic biomarkers and therapeutic targets for PE.

Main Methods:

  • Downloaded and analyzed mRNA, miRNA, and circRNA expression profiles from the GEO database for preeclampsia and normal pregnancy samples.
  • Utilized bioinformatics to identify differentially expressed genes (DEGs) and construct a competing endogenous RNA (ceRNA) network.
  • Validated expression profiles using RT-qPCR and existing GEO datasets.

Main Results:

  • Identified 1645 differentially expressed mRNAs (DEmRNAs), 41 DEmiRNAs, and 2432 DEcircRNAs.
  • Constructed a ceRNA network involving 3 circRNAs, 3 miRNAs, and 63 mRNAs.
  • Expression validation results were consistent with the integrated bioinformatics analysis.

Conclusions:

  • Speculated that specific circRNA-miRNA-mRNA axes, including hsa_circRNA_0001687/hsa-miR-532-3p/MMP14/AXL, hsa_circ_0001513/hsa-miR-188-5p/HMGCS1, and hsa_circ_0001513/hsa_circ_0001329/hsa-miR-760/MAP1LC3B, may play a role in the pathological processes of preeclampsia.
  • These findings suggest potential novel molecular targets for preeclampsia intervention.
Abstract

Keywords:
GEOPreeclampsiaceRNA networkcircRNA

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