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Updated: Oct 4, 2025

Author Spotlight: Integrating 2D-HPLC-MS and Molecular Networking in Natural Medicine Analysis
Published on: December 8, 2023
Anti-tumor alkaloids from Peganum harmala
Qin Zhang1, Yan-Hui Zan1, Han-Gao Yang1
1Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Abstract:
Six alkaloids peharmalines F-K, along with 14 known ones, were isolated from the aerial part of Peganum harmala L.. The structures of the isolated compounds were determined based on their HR-ESI-MS data, extensive NMR spectroscopic analyses, and ECD calculations. 3-(4-Hydroxyphenyl)quinoline exhibited potent antiproliferative activity against the HepG-2 cell lines with an IC50 value of 3.05 μM. Norharmane displayed a moderate inhibition against A549 and HepG-2 cells with IC50 values of 16.45 μM and 17.27 μM, respectively.
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