Expression and prognostic analysis of STAT6(YE361) in Hodgkin lymphoma

This study aimed to investigate the expression and prognostic significance of the signal transducer and activator of transcription protein 6 (STAT6^YE361) and EB virus encoding a small molecule RNA (EBER) in Hodgkin lymphoma (HL), as well as their correlation with clinical parameters. The expression of STAT6^YE361 and EBER was investigated in HL via immunohistochemistry and in situ hybridization. Patient clinical data were retrospectively collected from archival libraries, and statistical analysis was performed. Overall, the nuclear positive expression rate of STAT6^YE361 was 46%, and the EBER positive expression rate was 57%. STAT6^YE361 was specifically expressed on the nucleus in cHL tissues. EBER was overexpressed in HL and had correlations with several clinical data, including age, gender, ethnicity, and primary cancer site. Interestingly, nuclear STAT6^YE361 expression was correlated with EBER expression. Based on survival analysis, the nuclear expression of STAT6^YE361 and female patients were associated with poor prognosis and were independent prognostic factors for five-year OS. These findings suggest that STAT6^YE361 is a potential valuable index in the differential diagnosis and prognosis of HL. The mechanism of STAT6^YE361 is related to Epstein-Barr virus infection.