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Cholinesterase phenotyping: clinical aspects and laboratory applications
Critical Reviews in Clinical Laboratory Sciences
|January 1, 1986
Summary
Accurate cholinesterase measurement in human serum is vital for diagnosing organophosphate poisoning and guiding succinylcholine treatment. Different methods are needed for enzyme activity and genetic typing, with specific enzyme substrates recommended for each.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Toxicology
Background:
- Cholinesterase activity measurement in human serum is crucial for clinical management.
- Essential for patients with suspected organophosphate insecticide poisoning.
- Important for managing prolonged paralysis after succinylcholine administration.
Purpose of the Study:
- To review factors causing cholinesterase abnormalities.
- To advise on appropriate investigation techniques.
- To differentiate between enzyme activity measurement and genotype determination.
Main Methods:
- Review of existing literature on cholinesterase measurement techniques.
- Analysis of factors influencing cholinesterase activity.
- Evaluation of enzyme inhibitors for phenotypic ascription.
Main Results:
- No single method is optimal for both enzyme activity measurement and genotype determination.
- Propionyl thiocholine is recommended for activity measurement.
- Benzoyl choline is recommended for genotype determination.
Conclusions:
- Accurate clinical management requires reliable cholinesterase measurement and phenotypic ascription.
- Distinct methods are necessary for assessing enzyme activity versus genetic status.
- Laboratories with infrequent requests should seek expert assistance.