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Related Concept Videos

Labeling DNA Probes03:31

Labeling DNA Probes

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Updated: Oct 4, 2025

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
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Strategies for developing DNA-encoded libraries beyond binding assays.

Yiran Huang1, Yizhou Li2,3, Xiaoyu Li4,5

  • 1Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, China.

Nature Chemistry
|February 5, 2022
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Summary
This summary is machine-generated.

DNA-encoded chemical libraries (DELs) are advancing drug discovery by identifying binders for protein targets. Recent innovations show DELs can now probe complex biological systems to find functional molecules and explore biology.

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Area of Science:

  • Biochemistry
  • Medicinal Chemistry
  • Chemical Biology

Background:

  • DNA-encoded chemical libraries (DELs) are a powerful technology in drug discovery.
  • DEL adoption and compatible chemistry advancements are rapidly expanding its applications.
  • Traditionally, DELs function as large-scale binding assays for protein targets.

Purpose of the Study:

  • To discuss recent advancements in using DELs within complex biological systems.
  • To highlight the potential of DELs in identifying functional molecular structures.
  • To explore the future role of DELs in drug discovery and fundamental biology.

Main Methods:

  • Review of recent innovations and applications of DNA-encoded chemical libraries.
  • Discussion of DEL capabilities in complex biological environments.
  • Analysis of DEL potential for identifying functional molecules.

Main Results:

  • DELs are increasingly capable of operating within complex biological systems.
  • DELs can identify molecular structures with desired functions or properties.
  • DEL technology is evolving beyond simple binding assays.

Conclusions:

  • Recent innovations enable DELs to interrogate complex biological targets effectively.
  • DELs show promise for discovering molecules that elicit specific functions.
  • Future developments position DELs as a key platform for drug discovery and biological exploration.