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Published on: May 26, 2021

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Clonal hematopoiesis and vascular disease

Kaushik Amancherla1, John A Wells1, Alexander G Bick2

  • 1Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Seminars in Immunopathology
|February 5, 2022
PubMed

Insights

Clonal hematopoiesis, common with aging, involves stem cell mutations that increase blood cancer risk and drive cardiovascular disease. Its role in autoimmune and inflammatory conditions requires further investigation.

Area of Science:

  • Hematology
  • Immunology
  • Cardiovascular Science

Background:

  • Somatic mutations in hematopoietic stem cells (HSCs) are frequent with aging, leading to clonal expansion known as clonal hematopoiesis.
  • Clonal hematopoiesis is linked to increased blood cancer risk, chronic inflammatory diseases, and atherogenesis.
  • Immune cells are identified as effector cells, prompting research into their role in chronic inflammatory conditions like rheumatologic disease.

Purpose of the Study:

  • To summarize current understanding of clonal hematopoiesis.
  • To focus on the established role of clonal hematopoiesis in cardiovascular disease and inflammation.
  • To explore the potential relationship between clonal hematopoiesis and autoimmune disease.

Main Methods:

  • Review of current literature on clonal hematopoiesis.
  • Analysis of the role of immune cells in clonal hematopoiesis-related inflammation.
  • Identification of knowledge gaps regarding clonal hematopoiesis and autoimmune disorders.

Main Results:

  • Clonal hematopoiesis of indeterminate potential (CHIP) involves mutations in cancer-associated genes, leading to clonal expansion without overt malignancy.
  • CHIP is causally linked to atherosclerotic cardiovascular disease and inflammation.
  • The potential contribution of CHIP to autoimmune disease pathogenesis is an area for future research.

Conclusions:

  • Clonal hematopoiesis is a significant factor in cardiovascular disease and inflammation.
  • Further research is needed to elucidate the role of clonal hematopoiesis in autoimmune diseases.
  • Understanding the interplay between HSCs, immune function, and chronic inflammatory conditions is crucial.

Keywords:
ASCVDAtherosclerosisCHIPClonal hematopoiesisVascular disease

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