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Part I Antimicrobial resistance: Bacterial pathogens of dermatologic significance and implications of rising
Saira George1, Fiorinda F Muhaj2, Celine D Nguyen3
1Department of Dermatology, MD Anderson Cancer Center, Houston, Texas.
Abstract:
Although the COVID-19 pandemic has been the defining global health crisis of our time, public health officials have been sounding the alarm of another ominous threat for years: an impending antimicrobial resistance crisis. In dermatology, antibiotics are often used for prolonged courses in the treatment of skin and soft tissue infections and common inflammatory skin conditions, increasing the risk of microbiome alteration and antibiotic-related adverse effects, all while exerting consequential selective pressures on both pathogenic and bystander bacteria. In this review, we hope to raise awareness of the crisis of antimicrobial resistance and review resistance concerns related to dermatology-relevant bacterial pathogens.
Insights
The growing antimicrobial resistance crisis poses a significant threat, particularly in dermatology where prolonged antibiotic use for skin conditions increases bacterial resistance and adverse effects.
Area of Science:
- Dermatology
- Microbiology
- Public Health
Background:
- Antimicrobial resistance (AMR) is a major global health threat.
- Antibiotics are frequently used in dermatology for skin infections and inflammatory conditions.
- Prolonged antibiotic use can lead to microbiome disruption and increased bacterial resistance.
Purpose of the Study:
- To raise awareness of the escalating antimicrobial resistance crisis.
- To review antibiotic resistance concerns pertinent to dermatology.
Main Methods:
- This study is a review of existing literature.
- It focuses on resistance patterns of bacteria relevant to dermatological conditions.
Main Results:
- Dermatological antibiotic use contributes to selective pressure on bacteria.
- This pressure can lead to the emergence of resistant strains.
- Adverse effects and microbiome alterations are associated with antibiotic use.
Conclusions:
- There is an urgent need to address antimicrobial resistance in dermatology.
- Careful antibiotic stewardship is crucial to mitigate resistance development.
- Further research into alternative treatments is warranted.
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