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Fusobacterium necrophorum oral infections - A need for guidance

Robert M Centor1, T Prescott Atkinson2, Li Xiao2

  • 1Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham VA Hospital, Birmingham, AL, USA.

Anaerobe
|February 5, 2022
PubMed

Insights

Fusobacterium necrophorum infections, including pharyngotonsillitis and Lemierre syndrome, lack standard treatment guidelines. Expert consensus is needed to guide management for these increasingly recognized bacterial infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Fusobacterium necrophorum, a gram-negative anaerobe, causes significant human infections.
  • Despite increased clinical data over 20 years, no standard treatment guidelines exist for F. necrophorum infections.

Purpose of the Study:

  • To review current data on F. necrophorum infections.
  • To highlight the need for consensus expert opinions on treatment strategies.
  • To address the lack of guidance for pharyngotonsillitis, peritonsillar abscess, and Lemierre syndrome.

Main Methods:

  • Literature review of clinical information on F. necrophorum.
  • Analysis of data regarding F. necrophorum's role in pharyngotonsillitis and peritonsillar abscess.
  • Examination of the current treatment approaches for Lemierre syndrome.

Main Results:

  • F. necrophorum is a recognized cause of pharyngotonsillitis, particularly in the 15-30 age group.
  • This bacterium is frequently implicated in recurrent peritonsillar abscesses in young adults.
  • There is a lack of antibiotic and anticoagulation studies for Lemierre syndrome, leading to variable clinical management.

Conclusions:

  • Consensus expert opinions are needed to establish treatment guidelines for F. necrophorum infections.
  • Clinical management of pharyngotonsillitis and peritonsillar abscess may need adjustment based on F. necrophorum findings.
  • Standardized treatment protocols for Lemierre syndrome are urgently required.
Keywords:
FusobacteriumLemierre syndromePeritonsillar abscessSore throatTonsillopharyngitis

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