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Heteroduplex stabilities in highly repetitive DNA. An hypothesis for the polymorphism of Plasmodium parasite
FEBS Letters
|March 3, 1986
Abstract:
Codon repeats encountered in DNA sequences may formally lead to several double-stranded structures of similar stabilities. This is observed in the highly repetitive sequences of some Plasmodium antigens (S-antigen, CS proteins). It is postulated that gene recombination may occur via various heteroduplex molecules thus leading to antigenic polymorphism of Plasmodium parasites.