Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitrate therapy for congestive heart failure.

J A Franciosa, L A Nordstrom, J N Cohn

    JAMA
    |August 4, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Rationale, design, and methods for a Coreg (carvedilol) Heart Failure Registry (COHERE). COHERE Participant Physicians.

    Journal of cardiac failure·2000
    Same author

    Exercise tolerance as a guide to therapeutic efficacy for heart failure : the potential for angiotensin receptor blockers.

    Circulation·1999
    Same author

    Innovation and clinical practice in an era of polypharmacy for heart failure.

    Journal of cardiac failure·1999
    Same author

    Racial differences in response to therapy for heart failure: analysis of the vasodilator-heart failure trials. Vasodilator-Heart Failure Trial Study Group.

    Journal of cardiac failure·1999
    Same author

    Beta-adrenergic blocking agents: past, present, and future perspectives.

    Coronary artery disease·1999
    Same author

    Arterial stiffness.

    Journal of hypertension·1999
    Same journal

    Alcohol-Related Liver Disease: A Review.

    JAMA·2026
    Same journal

    Online Prescribing of GLP-1 Receptor Agonists.

    JAMA·2026
    Same journal

    Using AI Disagreement to Expose Gaps in Coverage Rules.

    JAMA·2026
    Same journal

    Randomized Trials in Pregnancy.

    JAMA·2026
    Same journal

    Randomized Trials in Pregnancy-Reply.

    JAMA·2026
    Same journal

    WHO Issues Guidelines for Treating Ebola and Marburg Viruses.

    JAMA·2026
    See all related articles

    Long-term vasodilator therapy with isosorbide dinitrate significantly improved congestive heart failure symptoms and exercise duration in a small trial. This suggests potential clinical benefits for patients with severe heart failure.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Severe congestive heart failure (CHF) presents significant challenges in management.
    • Long-term vasodilator therapy is explored as a potential treatment modality for CHF.

    Purpose of the Study:

    • To evaluate the efficacy and safety of long-term isosorbide dinitrate therapy in patients with severe congestive heart failure.

    Main Methods:

    • A randomized, double-blind, crossover trial involving 16 patients with severe CHF.
    • Patients received isosorbide dinitrate or placebo for eight weeks, followed by crossover to the alternative treatment.
    • Standard maintenance therapy with digitalis and diuretics was continued throughout the study.

    Main Results:

    • Fewer morbid events occurred with isosorbide dinitrate (7 events) compared to placebo (17 events).

    Related Experiment Videos

  • All patients receiving isosorbide dinitrate showed improved CHF severity, versus only two with placebo.
  • Maximal exercise duration significantly increased with isosorbide dinitrate (+2.54 minutes) but not with placebo (+1.24 minutes).

    • Conclusions:

    • Long-term isosorbide dinitrate therapy demonstrated potential clinical benefits in severe congestive heart failure.
    • The study suggests that vasodilators may be a valuable addition to standard CHF treatment.
    • Further research is warranted to confirm these preliminary findings.