Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anorexia Nervosa01:28

Anorexia Nervosa

265
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
265
Bulimia Nervosa01:30

Bulimia Nervosa

236
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
236
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

2.8K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
2.8K
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

4.2K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
4.2K
Binge Eating Disorders01:23

Binge Eating Disorders

211
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
211
Brain Imaging01:14

Brain Imaging

362
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
362

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IBS stress reactivity phenotype is associated with blood transcriptome profiles and microstructural and functional brain changes.

Neurobiology of stress·2026
Same author

Brain Changes Underlying Irritable Bowel Syndrome Symptom Improvement in Response to Mindfulness-Based Stress Reduction.

Neurogastroenterology and motility·2026
Same author

A Randomized Trial Testing a Body-Focused Exposure Treatment of Functional Abdominal Pain in Children.

The American journal of gastroenterology·2026
Same author

Sensory Over-Responsivity in Autism: A Bidirectional Brain-Gut-Microbiome Model.

Journal of autism and developmental disorders·2026
Same author

Exploring Sex Differences in Irritable Bowel Syndrome Prevalence, Environmental Risk, and Comorbidities: A Population-Based Cohort Study of Veterans.

Clinical and translational gastroenterology·2026
Same author

Recommendations for the inclusion and study of sex and gender in research.

Nature neuroscience·2025
Same journal

A bibliometric analysis of eating disorders in adolescents.

Journal of eating disorders·2026
Same journal

Intrafamilial concordance in perceived family dysfunction among children with eating disorders and their parents.

Journal of eating disorders·2026
Same journal

The intensive outreach programme for child and adolescent eating disorders: an uncontrolled case series of clinical characteristics and treatment outcomes.

Journal of eating disorders·2026
Same journal

Cardiovascular risk factors and serious health events in individuals with eating disorders: a systematic review.

Journal of eating disorders·2026
Same journal

Do new labels solve old problems? Conceptual, ethical, and clinical challenges of constructing restrictive eating behaviours as "self-harm".

Journal of eating disorders·2026
Same journal

Adaptation of the Barcelona Bipolar Eating Disorder Scale to Turkish and investigation of its validity and reliability.

Journal of eating disorders·2026
See all related articles

Related Experiment Video

Updated: Oct 4, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.3K

Complex functional brain network properties in anorexia nervosa.

Arpana Gupta1,2,3, Ravi R Bhatt4,5, Alannah Rivera-Cancel6

  • 1G. Oppenheimer Center for Neurobiology of Stress and Resilience, UCLA, Los Angeles, CA, 90095, USA. AGupta@mednet.ucla.edu.

Journal of Eating Disorders
|February 6, 2022
PubMed
Summary
This summary is machine-generated.

Anorexia nervosa (AN) is linked to altered brain network communication, showing reduced sensorimotor connectivity and increased basal ganglia activity. These neural differences correlate with core AN symptoms like body dissatisfaction.

Keywords:
Anorexia nervosaBasal gangliaFunctional connectivityNetwork metricsSensorimotor network

More Related Videos

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

389
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.2K

Related Experiment Videos

Last Updated: Oct 4, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.3K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

389
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.2K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Anorexia nervosa (AN) involves intense fear of weight gain and body perception disturbances, driving dangerous weight loss.
  • Neuroimaging studies reveal atypical brain activity in networks for interoception and reward processing in AN.

Purpose of the Study:

  • To model functional brain network architecture using resting-state neuroimaging.
  • To characterize brain region network properties in adolescents with AN compared to healthy controls (HCs).

Main Methods:

  • Resting-state neuroimaging was used in 62 adolescents (22 with AN, 40 HCs).
  • Whole-brain networks (165 regions) focused on sensorimotor and basal ganglia regions.
  • Network centrality and connectivity were analyzed using general linear models and correlations with clinical measures.

Main Results:

  • Adolescents with AN showed lower sensorimotor connectivity and higher connectivity from the left caudate nucleus to the right postcentral gyrus compared to HCs.
  • AN group exhibited reduced sensorimotor centrality but increased basal ganglia centrality.
  • Sensorimotor network properties negatively correlated with body dissatisfaction and drive for thinness.

Conclusions:

  • AN is associated with increased basal ganglia communication and decreased information propagation in sensorimotor cortices.
  • Findings align with AN's clinical features of rigid behaviors and a "disconnect" from bodily sensations.