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Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
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[Research Advances on the Role of Bone Marrow Stromal Cell in Acute Lymphoblastic Leukemia --Review]

Jun-Nan Kang1, Ze-Hui Chen1, Chen Tian2

  • 1Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|February 6, 2022
PubMed

Acute lymphoblastic leukemia (ALL) is a kind of the most common hematopoietic malignancy, its recurrence and drug resistance are closely related to the bone marrow microenvironment. Bone marrow stromal cell (BMSC) is an important part of the bone marrow microenvironment and their interaction with leukemia cells cannot be ignored. BMSC participates in and regulate signaling pathways related to proliferation or apoptosis of ALL cells by secretes cytokines or extracellular matrix proteins, thus affecting the survival of ALL cells. In this review, the research advance of several signaling pathways of the interaction between BMSC and ALL cells was summarized briefly.

Keywords:
acute lymphoblastic leukemiaapoptosisbone marrow stromal celldrug resistanceproliferation

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