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Ageing and small-bowel mucosa: a morphometric study.

G R Corazza, M Frazzoni, M R Gatto

    Gerontology
    |January 1, 1986
    PubMed
    Summary
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    Ageing does not directly reduce small intestine mucosal surface area. This study found no significant differences in jejunal surface area or enterocyte height between elderly and younger individuals, disputing age-related malabsorption.

    Area of Science:

    • Gastroenterology
    • Aging Research
    • Human Physiology

    Background:

    • Malnutrition and malabsorption are common in the elderly.
    • A direct effect of aging on reducing small intestine mucosal surface area is debated.
    • Previous studies have not conclusively determined if age-related changes in the small intestine contribute to malabsorption.

    Purpose of the Study:

    • To morphometrically evaluate jejunal biopsy specimens from elderly and younger individuals.
    • To determine if aging directly reduces the mucosal surface area of the small intestine.
    • To investigate the relationship between age and jejunal morphology.

    Main Methods:

    • Quantitative histology was performed on jejunal biopsy specimens.
    • Surface area to volume ratio of jejunal mucosa was calculated.

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  • Mean enterocyte height was measured in elderly patients and younger controls.

    • Main Results:

    • The mean surface area to volume ratio in geriatric patients (97.6 +/- 18) was not significantly different from younger controls (107.6 +/- 26).
    • No significant correlation was found between surface to volume ratio and age.
    • Mean enterocyte height in the elderly group (30.1 +/- 1.2 microns) did not significantly differ from younger controls (31.3 +/- 2.3 microns).

    Conclusions:

    • The reduction in jejunal surface area is not a direct consequence of aging.
    • Malnutrition due to malabsorption in the elderly should not be attributed solely to age-related decreases in jejunal surface area.
    • Further research is needed to identify other causes of malabsorption in the elderly population.