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Articles linked to this work by shared authors, journal, and citation graph.

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Editorial Commentary: Useful Considerations When Adding Lateral Extra-articular Procedures to Augment Anterior Cruciate Ligament Reconstruction in Skeletally Immature Patients.

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Updated: Oct 4, 2025

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
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Editorial Commentary: Biologic Augmentation of Meniscus Repair Is Complex.

Nikolaos K Paschos

    Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
    |February 6, 2022
    PubMed
    Summary

    Biological augmentation for meniscus repair is complex, requiring evaluation of numerous factors like cell source and growth factors. Optimal healing depends on a multifactorial approach, not just quantity, acknowledging that not all repairs succeed.

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    Area of Science:

    • Orthopedic surgery
    • Regenerative medicine
    • Biomaterials science

    Background:

    • Biological augmentation for meniscus repair involves complex biological agents.
    • Evaluating effectiveness, costs, risks, benefits, and limitations is crucial.

    Discussion:

    • Healing is influenced by aspirate source, cell type (including stem cells), growth factors, cytokines, scaffold biomechanics, and tissue quality.
    • Differences in mesenchymal, adipose, and peripheral blood stem cells impact differentiation potential.
    • Aspirate sources and fibrin clots vary in cellular and molecular content.

    Key Insights:

    • Optimal meniscus repair is not a simple 'more is better' scenario; varying doses of growth factors have differential effects on cell types.
    • Synergistic interactions between cells and growth factors significantly influence outcomes.
    • The biomechanical environment, healing phase timing, and patient-specific characteristics are critical variables.

    Outlook:

    • Extensive research is needed to fully understand the intricate factors governing successful meniscus repair.
    • Acknowledging the inherent limitations, not all meniscus repairs may achieve complete healing.