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Tinker, tailor, antiviral: RNA virus inhibition by induced recombination
Emmanuelle Pitre1, Aartjan J W Te Velthuis2
1Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK; Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
Trends in Biochemical Sciences
|February 6, 2022
Abstract:
Nucleotide analogs can help to combat RNA virus growth by stalling the viral RNA polymerase or by introducing lethal mutations into the viral genome. Janissen and Woodman et al. have used single-molecule, sequencing, and virological methods to reveal that antiviral T-1106 provides a third mechanism of counterattack: inducing recombination.