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Updated: Oct 4, 2025
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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
877
Multimeric G-quadruplexes: A review on their biological roles and targeting
Ilaria Frasson1, Valentina Pirota2, Sara N Richter1
1Department of Molecular Medicine, University of Padova, via A. Gabelli 63, 35121 Padova, Italy.
International Journal of Biological Macromolecules
|February 6, 2022
Summary
G-quadruplexes (G4s) are crucial nucleic acid structures. Multimeric G4s form in key human genome regions, influencing cellular processes and disease pathogenesis.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Nucleic acids form non-canonical structures regulating cellular processes.
- G-quadruplexes (G4s) are stable, guanine-rich structures influencing genome replication, transcription, and translation.
- G4 folding is implicated in genomic instability.
Purpose of the Study:
- To explore the structural properties, biological roles, and targeting strategies of multimeric G-quadruplexes.
- To highlight the significance of multimeric G4s in human cellular processes and disease.
Main Methods:
- Review of existing literature on G-quadruplex structures and functions.
- Analysis of G-quadruplex formation in critical human genomic regions.
- Discussion of potential therapeutic targeting strategies for multimeric G4s.
Main Results:
- G-quadruplexes can multimerize through various mechanisms, forming higher-order structures.
- Multimeric G4s are found in crucial genomic areas like telomeres and neuron-specific genes.
- These structures exhibit dual roles, potentially protective or detrimental in disease.
Conclusions:
- Multimeric G4s represent a complex regulatory mechanism in human cells.
- Understanding their structure and function is vital for comprehending cellular processes and disease.
- Targeting multimeric G4s offers potential therapeutic avenues.
