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Updated: Oct 4, 2025

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation
Published on: March 17, 2023
Isolated tricuspid regurgitation: A plea for early correction
Alessandra Sala1, Roberto Lorusso2, Ottavio Alfieri1
1Vita-Salute San Raffaele University, Department of Cardiac Surgery, IRCCS San Raffaele Hospital, Milan, Italy.
Severe isolated tricuspid regurgitation (TR) significantly impacts survival and requires timely intervention. Early surgical correction offers excellent outcomes, challenging previous management approaches for this condition.
Area of Science:
- Cardiology
- Cardiac Surgery
- Heart Valve Disease
Background:
- Isolated tricuspid regurgitation (TR) is increasingly recognized as a significant clinical entity.
- Untreated severe TR is associated with worsened patient survival.
- Current management strategies for severe isolated TR are debated, with stand-alone surgery infrequently performed due to perceived high mortality risks.
Purpose of the Study:
- To evaluate the outcomes of early surgical correction for severe isolated tricuspid regurgitation.
- To assess the impact of timely intervention on patient survival and long-term results.
- To provide evidence supporting a revised approach to the management and referral of patients with severe isolated TR.
Main Methods:
- Review of recent data on patients undergoing surgical correction for severe isolated tricuspid regurgitation.
- Analysis of in-hospital mortality, short-term, and long-term survival rates post-surgery.
- Assessment of subsequent hospitalizations for right heart failure.
Main Results:
- Early referral and surgical correction of severe isolated TR yield excellent short- and long-term results.
- No in-hospital mortality was observed in patients undergoing timely surgical intervention.
- A 100% 5-year survival rate and no further hospitalizations for right heart failure were reported.
Conclusions:
- Recent data demonstrate that early surgical intervention for severe isolated TR leads to superior outcomes.
- These findings necessitate a re-evaluation of current treatment paradigms, management protocols, and referral practices for severe isolated TR.
- Surgical correction remains the sole effective therapeutic option for severe isolated tricuspid regurgitation.
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