Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell-mediated immunity in rheumatic disease.

S J Padula, R B Clark, J H Korn

    Human Pathology
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A hybrid approach to skill retention following neonatal resuscitation training: Assessing effectiveness.

    Journal of neonatal-perinatal medicine·2024
    Same author

    Enhanced TLR2 responses in multiple sclerosis.

    Clinical and experimental immunology·2018
    Same author

    ATP triggers a robust intracellular [Ca<sup>2+</sup> ]-mediated signalling pathway in human synovial fibroblasts.

    Experimental physiology·2018
    Same author

    Current-Voltage Relationship for Late Na(+) Current in Adult Rat Ventricular Myocytes.

    Current topics in membranes·2016
    Same author

    Cellular electrophysiological principles that modulate secretion from synovial fibroblasts.

    The Journal of physiology·2016
    Same author

    Constraints on the process of interresponse-time reinforcement as the explanation of variable-interval performance.

    Behavioural processes·2014

    Systemic rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma involve immune dysfunction. While sharing some features, each condition exhibits distinct immune system abnormalities and distinct disease pathways.

    Area of Science:

    • Immunology
    • Rheumatology
    • Pathogenesis

    Background:

    • Systemic rheumatic diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc), are characterized by immune system dysregulation.
    • Understanding the specific immune defects in these conditions is crucial for elucidating their distinct pathogenetic mechanisms.

    Purpose of the Study:

    • To delineate the characteristic abnormalities of the cellular immune system in RA, SLE, and SSc.
    • To compare and contrast the immunopathogenesis of these three common systemic rheumatic diseases.

    Main Methods:

    • Review and synthesis of existing literature on immune system abnormalities in RA, SLE, and SSc.
    • Analysis of cellular and humoral immune function defects specific to each disease.

    Related Experiment Videos

    Main Results:

    • Rheumatoid arthritis shows immunoregulation abnormalities primarily linked to Epstein-Barr virus and collagen.
    • Systemic lupus erythematosus is marked by heightened B-cell activity, diverse autoantibodies, and suppressed cell-mediated immunity.
    • Systemic sclerosis exhibits milder immune defects, with lymphokines and monokines potentially driving inflammation.

    Conclusions:

    • Despite shared clinical and serological features, rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis possess distinct immune defects.
    • The immunopathogenesis of these systemic rheumatic diseases varies significantly, highlighting the need for disease-specific therapeutic strategies.