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Sinus histiocytosis with massive lymphadenopathy simulating subacute thyroiditis.
Human Pathology
|March 1, 1986
Summary
Sinus histiocytosis with massive lymphoadenopathy (SHML) can affect the thyroid gland, causing a painful goiter. This rare condition in the thyroid resolved on its own in a documented case.
Area of Science:
- Endocrinology
- Pathology
- Oncology
Background:
- Sinus histiocytosis with massive lymphoadenopathy (SHML), also known as Rosai-Dorfman disease, is a rare benign condition.
- While typically affecting lymph nodes, extranodal involvement can occur, including the thyroid gland.
Observation:
- A case of SHML presenting with a painful goiter and cervical lymphadenopathy in a white woman.
- Biochemical hypothyroidism was noted, yet the patient remained clinically euthyroid.
- Histological confirmation of SHML in both thyroid and cervical lymph node tissues.
Findings:
- SHML can manifest as a painful goiter and cervical lymphadenopathy.
- The thyroid gland can be an extranodal site for SHML.
- Spontaneous remission of SHML affecting the thyroid and cervical lymph nodes occurred in this patient.
Implications:
- This case expands the understanding of extranodal manifestations of SHML.
- Highlights the importance of considering SHML in the differential diagnosis of thyroid masses and cervical lymphadenopathy.
- Suggests that SHML involving the thyroid may have a benign and self-limiting course.