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Updated: Oct 4, 2025

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
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Roles of fusion genes in digestive system cancers: Dawn for cancer precision therapy

Yaqing Zhang1, Jie Sun1, Yongxi Song1

  • 1Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China; Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, 155 North Nanjing Street, Heping District, Shenyang 110001, China.

Critical Reviews in Oncology/Hematology
|February 6, 2022
PubMed

Insights

Personalized cancer treatment for advanced digestive system tumors is crucial. This review covers fusion gene detection, current guideline targets, and future therapeutic strategies for digestive cancers.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Advanced digestive system cancers require personalized treatment strategies.
  • Next-generation sequencing (NGS) has improved the detection of fusion genes in solid tumors.
  • Fusion genes are increasingly recognized as actionable targets in cancer therapy.

Purpose of the Study:

  • To review current methods for detecting fusion genes in digestive system cancers.
  • To discuss fusion genes already incorporated into treatment guidelines.
  • To explore potential novel fusion gene targets for future therapies.

Main Methods:

  • Literature review of current detection techniques for fusion genes.
  • Analysis of established and emerging fusion gene targets in digestive tract tumors.
  • Discussion of clinical applicability and future directions for fusion gene-targeted therapies.

Main Results:

  • NGS technologies enable extensive detection of fusion genes in solid tumors.
  • Specific fusion genes, like NTRK and FGFR2, are included in current digestive cancer treatment guidelines.
  • Numerous other fusion genes are under investigation as potential therapeutic targets.

Conclusions:

  • Fusion gene detection and targeted therapies offer promising avenues for personalized treatment in digestive system cancers.
  • Continued research into novel fusion genes and detection methods is essential for advancing clinical practice.
  • Targeting fusion genes holds significant potential for improving outcomes in digestive cancer patients.
Keywords:
CancerDigestive systemFusion geneTargeted therapy

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