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Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
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Brain structure-function coupling provides signatures for task decoding and individual fingerprinting.

Alessandra Griffa1, Enrico Amico2, Raphaël Liégeois2

  • 1Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland; Center of Neuroprosthetics, Ecole Polytechnique Fédérale De Lausanne (EPFL), Institute of Bioengineering, Geneva, Switzerland.

Neuroimage
|February 6, 2022
PubMed
Summary
This summary is machine-generated.

Brain structure-function coupling effectively decodes brain states and identifies individuals. Key information for individual identification resides in specific functional signal patterns within the fronto-parietal network.

Keywords:
DecodingFingerprintingFunctional connectivityGraph signal processingTaskfMRI

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Area of Science:

  • Neuroscience
  • Graph Signal Processing
  • Brain Imaging

Background:

  • Brain signatures are used for decoding brain states and individual identification.
  • Current methods do not integrate underlying brain anatomy with function.
  • Graph signal processing (GSP) reveals spatial gradients in structure-function coupling.

Purpose of the Study:

  • To investigate the specificity of structure-function coupling for distinct brain states and individuals.
  • To explore the role of GSP-based signal filtering and functional connectivity (FC) decomposition.

Main Methods:

  • Used multimodal magnetic resonance imaging (MRI) from 100 healthy subjects (Human Connectome Project).
  • Analyzed data during rest and seven different tasks.
  • Employed support vector machine classification for decoding and fingerprinting tasks.

Main Results:

  • Structure-function coupling measures enabled accurate classification for both task decoding and individual fingerprinting.
  • Frontoparietal network contributions were crucial for fingerprinting, localized in the 'liberal' functional signal portion.
  • The 'liberal' functional signal portion strongly correlated with cognitive traits.

Conclusions:

  • Brain structure-function coupling offers novel signatures for cognition and individual brain organization.
  • These findings clarify the roles of low and high spatial frequencies in the structural connectome.
  • Provides new understanding of where to find key structure-function information for individual characterization.