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Prospective Memory and Default Mode Network Functional Connectivity in Normal and Pathological Aging.

Yen-Hsuan Hsu1,2, Sheng-Min Huang3, Shih-Yeh Lin4

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Summary
This summary is machine-generated.

Alzheimer's disease impairs prospective memory (PM) by altering functional connectivity (FC) within the default mode network (DMN). This study reveals distinct DMN connectivity patterns associated with PM deficits in Alzheimer's patients compared to healthy aging.

Keywords:
Alzheimer’s diseasecerebral small vessel diseasedefault mode networkmemory for intentionprospective memory

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Medical Imaging

Background:

  • Prospective memory (PM), crucial for executing intentions, is vulnerable in Alzheimer's disease (AD).
  • Frontoparietal networks are implicated, but other neural substrates supporting spontaneous cognition may also be involved.
  • The default mode network (DMN) is a key network for internally directed thought and may play a role in PM.

Purpose of the Study:

  • To investigate the hypothesis that PM deficits in AD are linked to altered functional connectivity (FC) within the DMN.
  • To compare DMN FC patterns between AD patients, other dementia patients, and cognitively normal individuals during a PM task.
  • To identify specific DMN connectivity alterations associated with PM performance in AD.

Main Methods:

  • Recruited 34 patients with very mild/mild dementia (17 AD, 17 vascular) and 22 cognitively normal older adults.
  • Administered a computerized prospective memory task and conducted resting-state functional magnetic resonance imaging (fMRI).
  • Performed seed-based FC analysis within the DMN at the group level.

Main Results:

  • Dementia groups exhibited poorer PM performance and altered DMN FC compared to controls.
  • In normal aging, FC between medial prefrontal cortex and precuneus/posterior cingulate cortex correlated with PM.
  • In AD, FC between the right precuneus and bilateral inferior parietal lobules correlated with PM.

Conclusions:

  • The DMN plays a significant role in prospective memory.
  • PM deficits in AD are associated with altered FC within posterior DMN hubs.
  • The spatial patterns of DMN alterations in AD-related PM deficits differ from those in normal aging.