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Pathophysiology of Diabetes01:20

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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CIDEC: A Potential Factor in Diabetic Vascular Inflammation.

Fang-Qiang Song1,2, Hui-Min Zhou1,3, Wei-Xuan Ma1

  • 1The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Journal of Vascular Research
|February 6, 2022
PubMed
Summary

Cell death-inducing DFF45-like effector C (CIDEC) contributes to diabetic vascular inflammation. Silencing CIDEC in diabetic rats reversed aortic inflammation and remodeling, suggesting CIDEC as a therapeutic target.

Keywords:
Aortic inflammationC1q/tumor necrosis factor-related protein-3Cell death-inducing DFF45-like effector CDiabetes

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Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Pathophysiology

Background:

  • Cell death-inducing DFF45-like effector C (CIDEC) is implicated in adipose inflammation.
  • The role of CIDEC in diabetic vascular inflammation is not well understood.

Purpose of the Study:

  • To investigate the role of CIDEC in diabetic aortic inflammation and remodeling.
  • To explore the therapeutic potential of targeting CIDEC in diabetic vascular complications.

Main Methods:

  • A type 2 diabetic rat model was established using a high-fat diet and streptozotocin.
  • Evaluated metabolic parameters, CIDEC and C1q/tumor necrosis factor-related protein-3 (CTRP3) expression via Western blot, and aortic histopathology.
  • Utilized gene silencing to assess the impact of reduced CIDEC on diabetic vasculopathy.

Main Results:

  • Diabetic rats showed increased CIDEC expression, aortic inflammation, and remodeling.
  • CIDEC gene silencing restored CTRP3 expression.
  • Silencing CIDEC ameliorated insulin resistance, aortic inflammation, and vascular remodeling in diabetic rats.

Conclusions:

  • CIDEC expression is elevated in diabetic aortic inflammation and remodeling.
  • CIDEC gene silencing effectively reverses diabetic aortic inflammation and remodeling.
  • CIDEC represents a potential therapeutic target for managing vascular complications in diabetes.