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Updated: Oct 4, 2025
09:36
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
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Analgosedation before Less-Invasive Surfactant Administration: A Systematic Review.
Sophie Tribolet1, Nadège Hennuy1, Diane Snyers1
1Neonatology Division, University Hospital of Liège, Liège, Belgium.
Neonatology
|February 6, 2022
Summary
Analgosedation during less-invasive surfactant administration (LISA) improves infant comfort and procedural conditions. While it increases transient respiratory events, it does not impact long-term outcomes, suggesting a favorable risk-benefit profile for this neonatal respiratory distress syndrome management technique.
Area of Science:
- Neonatalogy
- Pediatric Critical Care
- Pharmacology
Background:
- Less-invasive surfactant administration (LISA) is recommended for preterm infants with respiratory distress syndrome.
- Analgosedation use during LISA is inconsistent among neonatologists.
- This review evaluates the efficacy and safety of analgosedation for LISA.
Approach:
- Systematic review of studies on sedation/analgesia for LISA.
- Searched MEDLINE, Embase, Scopus, and Cochrane Library.
- Included 8 studies (1 RCT) with 945 infants.
Key Points:
- Analgosedation significantly reduced infant pain and improved comfort.
- Procedural success was high (83% good/excellent) with analgosedation.
- No difference in treatment failure (intubation, repeat surfactant) or 24/72h mechanical ventilation.
- Increased desaturation and need for positive pressure ventilation during procedure.
- No significant difference in clinical tolerance or complications (hypotension, mortality, air leaks).
Conclusions:
- Analgosedation enhances infant comfort and procedural conditions during LISA.
- Limited impact on clinical evolution, but optimal drug choice and dosage require further study.
- Need for spontaneous breathing and rapid drug offset are key considerations for future research.
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