Related Experiment Video

Updated: Oct 4, 2025

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions
02:09

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions

Published on: December 20, 2024

406

Local glucose metabolism is unaltered in reversible splenial lesion syndrome

Johann Philipp Zöllner1,2, Jennifer Wichert3, Susanne Schubert-Bast2,4

  • 1Department of Neurology and Epilepsy Center Frankfurt Rhine-Main, Goethe University Frankfurt, Frankfurt am Main, Germany.

European Journal of Neurology
|February 6, 2022
PubMed
Abstract

Insights

Reversible splenial lesion syndrome (RESLES) involves swelling in the brain

Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Transient splenial oedema, or reversible splenial lesion syndrome (RESLES), is a rare MRI finding.
  • RESLES presents as focal oedema in the posterior corpus callosum and is linked to various clinical conditions.
  • The exact cause of RESLES remains unclear.

Purpose of the Study:

  • To investigate conflicting pathophysiological hypotheses of RESLES.
  • To measure local glucose metabolism in patients diagnosed with RESLES.

Main Methods:

  • Retrospective analysis of RESLES patients undergoing EEG monitoring after antiseizure medication reduction.
  • Measurement of local glucose uptake using PET/CT scans.
  • Comparison of matched cohorts with and without RESLES using non-parametric tests.

Main Results:

  • No significant difference in local glucose metabolism was observed in the splenium of RESLES patients compared to controls.
  • This finding held true for both regular and normalized glucose uptake value calculations.
  • Statistical analysis showed no significant difference (p = 0.902 and p = 0.535).

Conclusions:

  • The study found no evidence of local glucose hypometabolism in RESLES.
  • This supports the hypothesis that RESLES represents intercellular, intramyelinic oedema.
  • This type of oedema is distinct from typical, irreversible intracellular cytotoxic oedema.
Keywords:
CLOCCDWIRESLEScorpus callosumencephalopathyoedema

More Related Videos

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes06:26

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Published on: March 28, 2025

454
Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device04:40

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device

Published on: November 4, 2022

1.2K

Related Concept Videos

Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
25.5K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
366
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
2.1K
Metabolic States of the Body: The Postabsorptive State01:18

Metabolic States of the Body: The Postabsorptive State

The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
664
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
2.7K
Glucose Absorption Into the Small Intestine01:26

Glucose Absorption Into the Small Intestine

Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
32.7K