Chronodisruption and cardiovascular disease
Antonio Garcia-Rios1, Jose M Ordovas2
1Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, 14004 Córdoba, Spain; CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Insights
Cardiovascular disease (CVD) risk increases with circadian disruption, a disturbance in biological rhythms. Addressing chronobiology is crucial for managing CVD and its associated health burdens.
Area of Science:
- Chronobiology and cardiovascular health.
- Focus on biological rhythms and disease.
- Temporal regulation in physiology.
Background:
- Cardiovascular disease (CVD) poses a significant global health challenge.
- Rising prevalence of cardiometabolic risk factors exacerbates CVD.
- Traditional risk factor control is insufficient to curb the CVD pandemic.
Purpose of the Study:
- To review evidence linking chronobiology to cardiovascular disease.
- To highlight the emerging role of circadian rhythms in CVD research.
- To advocate for the integration of chronobiology into clinical practice.
Main Methods:
- Review of scientific literature on chronobiology and CVD.
- Analysis of studies on circadian disruption and cardiovascular risk.
- Synthesis of evidence on the impact of disturbed biological rhythms.
Main Results:
- Circadian disruption significantly elevates the risk of developing CVD.
- Chronobiology offers a novel perspective on CVD pathogenesis.
- Disturbances in physiological rhythms are linked to increased cardiovascular risk.
Conclusions:
- Chronobiology is a critical emerging field for understanding and managing CVD.
- Addressing circadian disruption is essential for combating the CVD pandemic.
- Translating chronobiological evidence into clinical practice is imperative.
Abstract:
Cardiovascular disease (CVD) is an important challenge for clinicians, researchers and governments to reduce the impact on the global health burden and socioeconomic costs. Moreover, far from diminishing, cardiometabolic risk factors leading to CVD development are on the rise. In order to stop the CVD pandemic, it is not enough to merely attempt to control traditional risk factors. In this regard, chronobiology, the science that studies biological rhythms, has become an important field in research in the last years. Circadian disruption or chronodisruption, defined as a relevant disturbance of the internal temporal order of physiological circadian rhythms significantly increases the risk of CVD. In this article we review some of the evidence that has made chronobiology one of the most emerging scenarios to take into account in routine clinical practice in which a translation of all this evidence should be mandatory.
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