Performance Evaluation of Fully Automated 5-Part Differential Hematology Analyzer ELite 580 (ERBA)

The ELite 580 (Erba Lachema) Hematology Analyzer is a newly developed automated hematology analyzer that uses impedance and flow cytometry technologies. The analyzer provides 25 reportable parameters including a 5-part differential and additionally 4 research parameters with a throughput of 80 samples per hour. To evaluate the performance of the fully automated 5-part differential hematology analyzer ELite 580 as per the international standards and correlate the results with a reference analyser, LH 780 from Beckman Coulter. We evaluated the analyzer's performance by determining background noise, carryover, precision, linearity and correlation of complete blood cell count parameters between the ELite 580 from Erba Lachema and the LH 780 from Beckman Coulter at a tertiary care hospital, according to the Clinical and Laboratory Standards Institute guidelines. The ELite 580 showed minimal background noise and carryover, high precision, accuracy and linearity over a wide analytical range for white blood cells, hemoglobin, red blood cells, hematocrit, and platelet parameters. Correlation between the ELite 580 and the LH 780 was good for all parameters (R² > 0.90) except for mean corpuscular hemoglobin concentration (MCHC) and the basophil count. ELite 580 Hematology Analyzer with its precise and accurate results and ease of operation is suitable for clinical use in medium to large sized hematology laboratories.

The online version contains supplementary material available at 10.1007/s12288-021-01423-y.