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Updated: Oct 4, 2025
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Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
Published on: September 9, 2020
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Novel technologies in cfDNA analysis and potential utility in clinic
Jie Li1, Mengyue Xu2, Junya Peng3
1Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
Chinese Journal of Cancer Research = Chung-Kuo Yen Cheng Yen Chiu
|February 7, 2022
Summary
Plasma cell-free DNA (cfDNA) profiling aids tumor diagnosis and monitoring. Emerging cfDNA technologies analyze epigenetic modifications, immune microenvironment, and microbiome for future clinical applications.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Plasma cell-free DNA (cfDNA) analysis is a rapidly advancing field in oncology.
- cfDNA profiling offers non-invasive insights into tumor characteristics.
Purpose of the Study:
- To review current cfDNA profiling technologies for tumor diagnosis, monitoring, and prognosis.
- To discuss emerging cfDNA assays and their potential clinical applications.
Main Methods:
- Review of existing literature on plasma cfDNA analysis techniques.
- Discussion of methods including mutation, copy number alteration, gene fusion, and DNA methylation analyses.
- Exploration of novel cfDNA assays reflecting epigenetic, immune, and microbiome status.
Main Results:
- Established cfDNA assays are valuable for routine clinical use.
- New laboratory-developed cfDNA technologies show promise for deeper biological insights.
- These advancements may inform future clinical decision-making.
Conclusions:
- Plasma cfDNA profiling is a powerful tool for cancer management.
- Continued development of cfDNA assays will enhance diagnostic and prognostic capabilities.
- Future research will focus on integrating these technologies into clinical practice.
