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Altered Neurovascular Coupling in Unilateral Pulsatile Tinnitus
Xiaoshuai Li1, Ning Xu1, Chihang Dai1
1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Pulsatile tinnitus (PT) patients show altered neurovascular coupling, with increased cerebral blood flow (CBF) to regional homogeneity (ReHo) ratios in specific brain regions. This suggests underlying neuropathological mechanisms in PT.
Area of Science:
- Neuroscience
- Medical Imaging
- Neurology
Background:
- Altered cerebral blood flow (CBF) and regional homogeneity (ReHo) are observed in pulsatile tinnitus (PT).
- Understanding neurovascular coupling is crucial for PT pathophysiology.
Purpose of the Study:
- To investigate regional neurovascular coupling alterations in PT patients.
- To correlate neurovascular coupling with clinical data in PT.
Main Methods:
- Arterial spin labeling MRI for CBF measurement.
- Functional MRI for ReHo computation.
- Analysis of the CBF/ReHo ratio in 24 PT patients and 25 controls.
Main Results:
- PT patients displayed an elevated CBF/ReHo ratio in the left middle temporal gyrus and right angular gyrus compared to controls.
- No decreased CBF/ReHo ratio was observed.
- A positive correlation was found between the left middle temporal gyrus CBF/ReHo ratio and Tinnitus Handicap Inventory score (r = 0.433, p = 0.035).
Conclusions:
- PT patients exhibit abnormal regional neurovascular coupling.
- These findings offer insights into the neuropathological basis of PT.
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