Related Experiment Video

Updated: Oct 4, 2025

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
10:32

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Published on: April 2, 2021

3.8K

How is insulin-like growth factor-1 correlated with retinopathy of prematurity?

Nahid Jafari1, Arezoo Karimi Moghadam2, Naeeme Taslimi Taleghani3

  • 1Department of Neonatology and Perinatology, Zanjan University of Medical Science, Zanjan, Iran.

Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences
|February 7, 2022
PubMed

Insights

Insulin-like growth factor-1 (IGF-1) levels did not show a significant association with retinopathy of prematurity (ROP) in premature infants. Further research is needed to understand factors influencing IGF-1 in ROP development.

Area of Science:

  • Neonatology
  • Pediatric Ophthalmology

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Insulin-like growth factor-1 (IGF-1) plays a crucial role in development and has been investigated for its potential association with ROP.

Purpose of the Study:

  • To evaluate the association between insulin-like growth factor-1 (IGF-1) levels and the presence of retinopathy of prematurity (ROP).

Main Methods:

  • IGF-1 levels were measured in 40 neonates with a gestational age <34 weeks and birth weight ≤2000 g at 1 week and 4-6 weeks after birth.
  • All participants underwent ROP evaluation after 31 weeks of gestation.

Main Results:

  • A significant difference in IGF-1 levels was observed between neonates weighing ≤1500 g and those weighing 1500-2000 g at both time points (P = 0.008 and P = 0.039).
  • No significant association was found between IGF-1 levels and the development of ROP.

Conclusions:

  • The current study did not find a significant link between IGF-1 and ROP.
  • Further investigation into factors influencing IGF-1 levels is necessary to understand its role in ROP pathogenesis.
Abstract

Keywords:
Insulin-like growth factor-1preterm birthretinopathy of prematurity

More Related Videos

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.2K
Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts05:56

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts

Published on: January 22, 2020

4.9K

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.2K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
1.7K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.6K