Related Experiment Video

Updated: Oct 4, 2025

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

11.6K

The relationship between hemoglobin A1c levels and thrombus load in patients with type 2 diabetes mellitus and

Dursun Topal1, Ferit Onur Mutluer2, Omur Aydin3

  • 1Department of Cardiology, Bursa Education and Research Hospital, Health Sciences University, Bursa, Turkey.

Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences
|February 7, 2022
PubMed

Insights

Higher hemoglobin A1c (HbA1c) levels in type-2 diabetes mellitus patients with non-ST segment elevation myocardial infarction (NSTEMI) correlate with increased coronary thrombus. Strict anticoagulation is advised for these patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Diabetology

Background:

  • Type-2 diabetes mellitus (T2DM) is a significant risk factor for cardiovascular diseases.
  • Non-ST segment elevation myocardial infarction (NSTEMI) is a common presentation of acute coronary syndrome.
  • The relationship between glycemic control and coronary thrombus burden in T2DM patients with NSTEMI requires further investigation.

Purpose of the Study:

  • To investigate the association between hemoglobin A1c (HbA1c) levels and coronary thrombus load in patients with T2DM and NSTEMI.
  • To compare thrombus burden between diabetic patients with controlled (HbA1c ≤6.5%) versus uncontrolled (HbA1c >6.5%) glycemic levels.

Main Methods:

  • Ninety T2DM patients diagnosed with NSTEMI were enrolled.
  • Patients were stratified into two groups based on HbA1c levels: Group I (≤6.5%) and Group II (>6.5%).
  • Coronary thrombus burden was assessed using Thrombolysis in Myocardial Infarction (TIMI) thrombus score and Syntax score.

Main Results:

  • Group II (HbA1c >6.5%) exhibited significantly higher TIMI thrombus scores and Syntax scores compared to Group I (HbA1c ≤6.5%).
  • Stepwise linear regression identified HbA1c as a significant predictor of coronary thrombus scale.
  • No significant correlation was found between thrombus formation and hypertension, prior PCI, heart rate, cholesterol, or high-sensitive troponin T.

Conclusions:

  • Elevated HbA1c levels (above 6.5%) are associated with a greater coronary thrombus burden in T2DM patients presenting with NSTEMI.
  • These findings suggest that tighter glycemic control may be crucial in managing coronary artery disease in this patient population.
  • Consideration of strict anticoagulation strategies is recommended to mitigate adverse cardiovascular events in T2DM patients with NSTEMI and elevated HbA1c.
Abstract

Keywords:
Coronary artery diseasecoronary thrombusdiabetes mellitushemoglobin A1cnon-ST elevation myocardial infarction

More Related Videos

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

570
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

406

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.1K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
975
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
911
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
72
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.4K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
428