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Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses

Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses

Published on: September 11, 2023

Molecular testing on serous effusion: An update.

Saumya Sahu¹, Parikshaa Gupta², Pranab Dey²

¹Department of Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

|February 7, 2022

Summary

This summary is machine-generated.

Diagnosing malignancy in effusion fluid can be difficult. Molecular tests on effusion samples offer valuable insights for diagnosis, personalized therapy, and prognosis.

Keywords:

Comparative genomic hybridization Cytology Diagnosis Fluorescent in situ hybridization Genetic markers Molecular testing Next-generation sequencing Polymerase chain reaction Serous effusion

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Area of Science:

Oncology
Cytopathology
Molecular Diagnostics

Background:

Cytological examination of effusion fluid aids in malignancy detection.
Diagnosing malignant cells in serous effusions presents challenges.
Ancillary techniques like immunocytochemistry and flow cytometry assist diagnosis.

Purpose of the Study:

To review the application of molecular tests in effusion samples.
To highlight the growing interest in molecular diagnostics for effusions.
To discuss the diagnostic and therapeutic potential of effusion molecular testing.

Main Methods:

Review of current literature on molecular tests in effusion samples.
Discussion of various molecular techniques applicable to effusions.
Analysis of the components within effusion fluid relevant to molecular analysis.

Main Results:

Effusion samples contain cells, cell-free DNA, cytokines, and extracellular vesicles.
Molecular tests provide diagnostic information for malignancy.
These tests offer crucial data for individualized therapy, management, and prognosis.

Conclusions:

Molecular testing of effusion samples is a rapidly advancing field.
These tests enhance diagnostic accuracy and therapeutic decision-making.
Effusion molecular analysis is essential for personalized cancer care.