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Hypermagnesaemia, but Not Hypomagnesaemia, Is a Predictor of Inpatient Mortality in Critically Ill Children with

Huabin Wang1,2, Junbin Huang1,2, Xinghan Jin3

  • 1Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, China.

Disease Markers
|February 7, 2022
PubMed

Insights

Hypermagnesemia (high serum magnesium) is a risk factor for mortality in children with sepsis in the pediatric intensive care unit. Hypomagnesemia (low serum magnesium) did not significantly impact mortality outcomes.

Area of Science:

  • Pediatric Critical Care Medicine
  • Clinical Chemistry
  • Sepsis Pathophysiology

Background:

  • Sepsis is a life-threatening condition in children, with prognosis influenced by various factors.
  • The role of serum magnesium levels in pediatric sepsis outcomes remains incompletely understood.
  • Accurate assessment of prognostic indicators is crucial for timely intervention in pediatric intensive care units (PICU).

Purpose of the Study:

  • To investigate the association between admission serum magnesium levels and inpatient mortality in pediatric sepsis patients.
  • To determine if hypermagnesemia or hypomagnesemia predicts mortality risk in critically ill children with sepsis.
  • To clarify the prognostic significance of serum magnesium in the PICU setting.

Main Methods:

  • Retrospective analysis of clinical data from a Pediatric Intensive Care database.
  • Inclusion of 974 critically ill children diagnosed with sepsis.
  • Statistical analyses including chi-square tests, Kaplan-Meier survival analysis, and multivariate logistic regression.

Main Results:

  • Hypermagnesemia was associated with significantly higher in-hospital mortality (14.5%) compared to the normal magnesium group (2.4%).
  • Kaplan-Meier analysis indicated lower 30-day survival rates in the hypermagnesemia group.
  • Multivariate regression identified hypermagnesemia as a significant risk factor for inpatient mortality (OR 4.22), while hypomagnesemia was not (OR 0.78).

Conclusions:

  • Serum hypermagnesemia is a significant predictor of inpatient mortality in critically ill children with sepsis.
  • Serum hypomagnesemia does not appear to be a significant predictor of mortality in this patient population.
  • These findings highlight the importance of monitoring magnesium levels in pediatric sepsis management.
Abstract

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