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Distribution and Risk Factors of Multidrug-Resistant Bacteria Infection in Orthopedic Patients
Maohua Liang1,2, Qiang Liu1
1Orthopcdics Department of Tai'an Central Hospital, Tai'an, Shandong 271000, China.
Objective:
To study the distribution and risk factors of multidrug-resistant bacteria (MDROS) infection in orthopedic patients and to provide reference for clinical prevention and control measures.
Methods:
The data of 239 inpatients with orthopedic trauma from June 2019 to December 2020 were selected as the research objects, and the distribution characteristics of MDROS infection were analyzed through the real-time monitoring system of nosocomial infection. Logistic regression analysis was used to screen out the risk factors causing MDROS infection, and the preventive measures were put forward.
Results:
178 strains of pathogens were isolated from 239 patients, including 53 strains of MDROS, and the detection rate was 29.78%. The main pathogenic bacteria were ESBLs, MRSA, CRAB, CRE, and MDR/PDRPA. The main infection sites of MDROS in orthopedic patients were the respiratory tract and wound. No CRE1 was detected, and 64.39%, 17.42%, and 14.39% of ESBL-producing bacteria, MRSA, and MDR/PDRPA, respectively, were detected. Logistic multivariate analysis showed that the length of hospital stay, antibiotic use time, open injury, and serum albumin level were independent risk factors of MDROS infection in orthopedic trauma patients.
Conclusion:
To prevent MDROS infection in orthopedic patients, we should start from many aspects, focusing on reducing unnecessary hospitalization days, rationally preventing the use of antibacterial drugs, effectively treating basic diseases, etc., timely and effective thorough debridement, strengthening functional training, reducing bed rest, and strengthening targeted monitoring of related infections which are the keys to reduce MDROS infection in orthopedic patients.
Insights
Multidrug-resistant organisms (MDROs) infect nearly 30% of orthopedic trauma patients, primarily in the respiratory tract and wounds. Key risk factors include longer hospital stays and antibiotic exposure, necessitating targeted prevention strategies.
Area of Science:
- Infectious Diseases
- Orthopedic Surgery
- Microbiology
Background:
- Multidrug-resistant organisms (MDROs) pose a significant threat in healthcare settings.
- Orthopedic patients are particularly vulnerable to hospital-acquired infections.
- Understanding the epidemiology of MDROs in this population is crucial for effective control.
Purpose of the Study:
- To determine the prevalence and distribution of MDRO infections in orthopedic trauma patients.
- To identify independent risk factors associated with MDRO acquisition in this cohort.
- To inform clinical strategies for preventing and managing MDRO infections.
Main Methods:
- Retrospective analysis of 239 orthopedic trauma inpatients from June 2019 to December 2020.
- Real-time monitoring system for nosocomial infections to track pathogen distribution.
- Logistic regression analysis to identify risk factors for MDRO infection.
Main Results:
- A total of 53 MDRO strains were detected, representing a 29.78% infection rate.
- Common MDROs included ESBL-producing bacteria, MRSA, CRAB, CRE, and MDR/PDRPA.
- Infection sites were primarily the respiratory tract and wounds. Independent risk factors identified were prolonged hospitalization, extended antibiotic use, open fractures, and low serum albumin levels.
Conclusions:
- MDRO prevention in orthopedic patients requires a multifaceted approach.
- Strategies should focus on optimizing hospital stay duration, rational antibiotic use, and prompt wound management.
- Enhanced surveillance and management of underlying conditions are key to reducing MDRO burden.
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