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Association of soluble receptor for advanced glycation end-products (sRAGE) serum on COVID-19 severity: A

Gusti Noor Ramadany Saputra1, Resti Yudhawati1, Munawaroh Fitriah2

  • 1Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

Annals of Medicine and Surgery (2012)
|February 7, 2022
PubMed

Insights

Serum soluble receptor for advanced glycation end-products (sRAGE) is significantly associated with COVID-19 severity. Higher sRAGE levels indicate a greater risk of severe illness, aiding in early detection of lung damage.

Area of Science:

  • Biomarkers and Disease Severity
  • Pulmonary Medicine
  • Infectious Diseases

Background:

  • Coronavirus disease 2019 (COVID-19) necessitates biomarkers for early tissue damage detection.
  • Soluble receptor for advanced glycation end-products (sRAGE) is a potential biomarker for early lung damage.

Purpose of the Study:

  • To analyze the association between serum sRAGE levels and COVID-19 severity.
  • To evaluate sRAGE as a potential indicator of lung damage in COVID-19 patients.

Main Methods:

  • Cross-sectional study with 145 participants (47 non-severe, 98 severe COVID-19 cases).
  • Analysis of serum sRAGE levels using statistical tests including chi-square, Fisher's exact, t-test, Mann Whitney, and Spearman's rank tests.
  • Evaluation of diagnostic performance with sensitivity, specificity, and AUC.

Main Results:

  • Significant differences in leukocytes, lymphocytes, neutrophils, procalcitonin, CRP, and D-dimer between severe and non-severe groups.
  • Significantly higher serum sRAGE levels in severe COVID-19 patients (1.47 ng/mL) compared to non-severe (0.78 ng/mL).
  • Strong positive association (r=0.598, p<0.001) between serum sRAGE and COVID-19 severity; cut-off value of 0.985 ng/mL with 73.5% sensitivity and 74.5% specificity.

Conclusions:

  • Serum sRAGE is significantly associated with COVID-19 severity.
  • Elevated serum sRAGE levels differentiate between severe and non-severe COVID-19 cases, suggesting its utility in assessing disease progression and lung damage.
Abstract

Keywords:
COVID-19 severityInfectious diseaseSerum sRAGE

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