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Related Experiment Videos

Naproxen in otitis media with effusion.

S Abramovich, J O'Grady, A Fuller

    The Journal of Laryngology and Otology
    |March 1, 1986
    PubMed
    Summary

    Prostaglandin E2 (PGE2) levels were measured in children with secretory otitis media. Naproxen did not significantly improve otalgia or hearing loss, suggesting non-steroidal anti-inflammatory drugs are unlikely to benefit this condition.

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    Area of Science:

    • Otolaryngology
    • Pediatrics
    • Pharmacology

    Background:

    • Secretory otitis media is a common pediatric condition.
    • Prostaglandin E2 (PGE2) is implicated in inflammatory processes.
    • The therapeutic efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) in secretory otitis media is not well-established.

    Purpose of the Study:

    • To measure PGE2 levels in middle ear effusions of children with secretory otitis media.
    • To evaluate the therapeutic effect of naproxen on otalgia and hearing loss in this condition.

    Main Methods:

    • A placebo-controlled, double-blind trial was conducted.
    • Middle ear aspirates were analyzed for PGE2 levels.
    • Patients received either naproxen or placebo for eight weeks.

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    Main Results:

    • Detectable PGE2 levels were found in 7 out of 19 middle ear aspirates.
    • PGE2 levels ranged from 1.0 to 14.4 ng/mL.
    • Naproxen showed no significant improvement in otalgia or hearing loss compared to placebo.

    Conclusions:

    • PGE2 may be present in middle ear effusions of children with secretory otitis media.
    • Naproxen did not provide significant therapeutic benefit.
    • NSAIDs are unlikely to be effective treatments for secretory otitis media.