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Clinical features and risk factors of severely and critically ill patients with COVID-19

Xin Chu1, Gui-Fang Zhang2, Yong-Ke Zheng3

  • 1Department of Surgical Intensive Care Medicine, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.

World Journal of Clinical Cases
|February 7, 2022
PubMed

Insights

Identifying severe COVID-19 cases early is crucial. Advanced age, elevated neutrophil-to-lymphocyte ratios, and high-sensitivity cardiac troponin I are key indicators for predicting severe coronavirus disease 2019 (COVID-19) progression.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Biomarkers

Background:

  • Over 370,000 global deaths reported by June 1, 2020.
  • Risk factors for severe coronavirus disease 2019 (COVID-19) remain unclear.

Purpose of the Study:

  • To identify characteristics of severely and critically ill COVID-19 patients.
  • To find predictive markers for severe COVID-19 progression.

Main Methods:

  • Retrospective study of 126 COVID-19 patients (moderate, severe, critical groups).
  • Data collected: demographics, clinical symptoms, outcomes, lab tests, and imaging.
  • Multivariate logistic regression analysis performed.

Main Results:

  • Age (OR=1.055), elevated neutrophil-to-lymphocyte ratio (OR=4.019), and elevated high-sensitivity cardiac troponin I (OR=10.126) identified as high-risk factors.
  • Significant differences in outcomes and laboratory values observed between patient groups.

Conclusions:

  • Age, elevated neutrophil-to-lymphocyte ratio, and high-sensitivity cardiac troponin I can help identify severe COVID-19 patients early.
  • These markers aid clinicians in risk stratification and timely intervention.
Abstract

Keywords:
Amino-terminal pro-brain natriuretic peptideAspartate transaminaseCOVID-19CalciumCreatinineCritically illRisk factorsSARS-CoV-2

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