The aqueous humor proteome is intrinsically disordered
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Updated: Oct 4, 2025

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
Published on: November 1, 2024
Mak Djulbegovic1, Vladimir N Uversky2,3
1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17St, Miami, FL, 33136, USA.
Abstract:
•Our study demonstrated that intrinsic disorder is abundant in the aqueous humor.•The 749 aqueous proteins analyzed were enriched with disorder-promoting residues.•208 aqueous humor proteins were predicted to be highly intrinsically disordered.•Misregulation of IDPs may promote pathology in the aqueous humor.•IDPs in aqueous humor may serve as future targets for novel therapeutics.
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