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Common genetic aspects between COVID-19 and sarcoidosis: A network-based approach using gene expression data
Md Roman Mogal1, Sagarika Adhikary Sompa1, Asadullah Junayed1
1Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Tangail, 1902, Bangladesh.
Biochemistry and Biophysics Reports
|February 7, 2022
Summary
This study identified five key genes common to COVID-19 and sarcoidosis, including VDR and NFE2L2. These findings may help guide treatment for patients with both conditions.
Area of Science:
- * Genomics and Bioinformatics
- * Immunology and Infectious Diseases
Background:
- * The COVID-19 pandemic poses a global health threat, with sarcoidosis patients facing increased risk of severe outcomes due to lung conditions and immunosuppressive treatments.
- * Physicians face challenges in managing immunosuppressive therapy for sarcoidosis patients who contract COVID-19, necessitating identification of common disease factors.
- * Understanding shared genetic factors is crucial for developing effective treatment strategies for co-occurring COVID-19 and sarcoidosis.
Purpose of the Study:
- * To identify common upregulated genes between COVID-19 and sarcoidosis.
- * To construct and analyze protein-protein interaction networks for these common genes.
- * To explore potential therapeutic targets, including transcription factors, miRNAs, and drugs.
Main Methods:
- * Gene Expression Omnibus (GEO) datasets (GSE164805, GSE18781) were analyzed to find common upregulated genes.
- * R language was used for gene identification, pathway, and Gene Ontology (GO) analysis.
- * STRING and Cytoscape tools were employed for constructing and analyzing protein-protein interaction (PPI) networks, identifying hub genes and modules.
Main Results:
- * A total of 34 common upregulated genes were identified between COVID-19 and sarcoidosis.
- * Five hub genes (TET2, MUC5AC, VDR, NFE2L2, BCL6) were pinpointed, with VDR and NFE2L2 forming a significant cluster.
- * Networks revealed 32 transcription factors, 9 miRNAs, and potential drug interactions, including vitamin D and its analogs.
Conclusions:
- * The identified hub genes may play critical roles in the pathogenesis of both COVID-19 and sarcoidosis.
- * These genes represent potential therapeutic targets for managing patients with co-infection or co-morbidity.
- * Further research is warranted to validate these findings and their clinical implications.
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