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Gene Transfer for Ischemic Heart Failure in a Preclinical Model
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Cardiac Gene Therapy With Relaxin Receptor 1 Overexpression Protects Against Acute Myocardial Infarction

Teja Devarakonda1,2, Adolfo G Mauro1, Chad Cain1

  • 1Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.

JACC. Basic to Translational Science
|February 7, 2022
PubMed

Keywords:
AAV, adeno-associated virusCMV, cytomegalovirusGLS, global longitudinal strainIR, ischemia-reperfusionLV functionLV, left ventricularMAPK, mitogen-activated protein kinaseMI, myocardial infarctionPV, pressure-volumeRXFP1RXFP1, relaxin family peptide receptor 1SIRO, simulated ischemia and reoxygenationVEC, empty vectoreNOS, endothelial nitric oxide synthasegene therapyischemia-reperfusion injurymRNA, messenger ribonucleic acidrelaxin

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