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Nucleic Acid Architectonics for pH-Responsive DNA Systems and Devices.

Mohamed Nabeel Mattath1,2, Debasis Ghosh1, Sumon Pratihar1

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This review explores pH-responsive nucleic acid architectures for diagnostics and therapeutics. These DNA nanostructures offer biocompatibility and programmability for advanced applications.

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Area of Science:

  • DNA nanotechnology
  • Molecular architectonics
  • Biocompatible materials

Background:

  • Nucleic acid-based architectures are crucial for DNA nanotechnology.
  • Molecular architectonics utilize base pairing for functional constructs.
  • pH-responsive nucleic acid systems are promising for diagnostics and therapeutics.

Purpose of the Study:

  • To review recent advancements in nucleic acid architectonics.
  • To focus on pH-driven molecular systems and their applications.
  • To highlight future challenges and opportunities in the field.

Main Methods:

  • Exploitation of conventional and unconventional base pairing interactions.
  • Integration of molecular partners into functional architectures.
  • Development of pH-responsive systems for targeted applications.

Main Results:

  • Discussion of molecular and nanoarchitectures.
  • Overview of templated architectures, nanoclusters, and nanomachines.
  • Exploration of hydrogels, targeted bioimaging, and drug delivery systems.

Conclusions:

  • pH-responsive nucleic acid systems offer significant potential.
  • Advancements in DNA nanotechnology enable novel applications.
  • Future research should address current challenges for broader implementation.