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Protocol for activity flow mapping of neurocognitive computations using the Brain Activity Flow Toolbox.

Carrisa V Cocuzza1,2, Ruben Sanchez-Romero1, Michael W Cole1

  • 1Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA.

STAR Protocols
|February 7, 2022
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Summary

Activity flow mapping reveals how brain activity generates cognitive processes. This new method models activity flow across neural connections to predict brain activations, offering insights into cognitive function.

Keywords:
BioinformaticsCognitive NeuroscienceComputer sciencesNeuroscienceSystems biology

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Area of Science:

  • Cognitive Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Traditional cognitive neuroscience maps cognitive processes to brain regions using task-evoked activations.
  • The underlying mechanisms generating these neurocognitive processes remain largely unknown.

Purpose of the Study:

  • To introduce and validate a novel approach, activity flow mapping, for identifying network mechanisms of neurocognitive process generation.
  • To provide a protocol for utilizing the Brain Activity Flow Toolbox to study these mechanisms.

Main Methods:

  • Activity flow mapping models the movement of task-evoked activity across brain connections.
  • This approach predicts task-evoked activations based on network flow dynamics.
  • The Brain Activity Flow Toolbox facilitates the implementation of this protocol.

Main Results:

  • Activity flow mapping empirically validates network mechanisms underlying neurocognitive process generation.
  • The method successfully models the dynamic flow of activity within brain networks.
  • Predictions of task-evoked activations align with empirical data.

Conclusions:

  • Activity flow mapping offers a powerful new framework for understanding how cognitive processes are generated in the brain.
  • This approach bridges the gap between regional brain activity and network-level mechanisms.
  • The Brain Activity Flow Toolbox provides a practical tool for researchers to apply this methodology.