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Diabetic autonomic neuropathy.

E Niakan, Y Harati, J P Comstock

    Metabolism: Clinical and Experimental
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Diabetic autonomic neuropathy (DAN), affecting up to 40% of diabetes patients, involves various organ systems and can be life-threatening. Early diagnosis via noninvasive tests is possible, though effective treatments remain elusive.

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    Area of Science:

    • Endocrinology
    • Neurology
    • Diabetology

    Background:

    • Diabetic autonomic neuropathy (DAN) is a common complication of diabetes mellitus, with an incidence ranging from 20% to 40%.
    • Symptoms of DAN are often subtle and difficult to detect during routine physical examinations.
    • DAN can impact multiple organ systems, including cardiovascular, gastrointestinal, genitourinary, and neuroendocrine functions, posing significant health risks.

    Purpose of the Study:

    • To highlight the prevalence and impact of diabetic autonomic neuropathy.
    • To emphasize the importance of early diagnosis of DAN.
    • To discuss diagnostic methods and the current state of therapeutic interventions for DAN.

    Main Methods:

    • Review of existing literature on diabetic autonomic neuropathy.

    Related Experiment Videos

  • Discussion of noninvasive diagnostic tests for identifying and localizing autonomic pathway lesions.
  • Exploration of potential therapeutic agents and the need for further research.

    • Main Results:

    • Diabetic autonomic neuropathy affects a substantial portion of individuals with diabetes mellitus.
    • Early detection of DAN is achievable through specific noninvasive tests.
    • The metabolic disturbances underlying peripheral neuropathy are implicated in DAN.

    Conclusions:

    • Diabetic autonomic neuropathy is a serious complication with potentially life-threatening consequences.
    • Noninvasive tests offer a viable approach for the early diagnosis and localization of DAN.
    • Current definitive therapies for DAN are unsatisfactory, necessitating continued investigation into chemotherapeutic agents.